Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

AD afflicts over 35 million people throughout the world, including 5.4 million individuals in the USA alone, with a new case developing every 66 sec. Synaptic loss is the best predictor of the clinical symptoms of AD and the mechanisms by which this deficit occurs is an intense area of investigation. Aβ oligomers have been classified as types 1 and 2; the latter appears to contribute to synaptotoxicity. Tau can translocate from axons to the...