Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds
Abstract
Insulin receptor (InsR) and the type I insulin-like growth factor (IGF1R) are homologous receptors necessary for signal transduction by their cognate ligands insulin, IGF-I and IGF-II. IGF1R mAbs, intended to inhibit malignant phenotypic signaling, failed to show benefit in patients with endocrine-resistant tumors in phase III clinical trials. Our previous work showed that in tamoxifen-resistant cells, IGF1R expression was lacking, but InsR...
Paper Details
Title
Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds
Published Date
Jul 1, 2017
Volume
16
Issue
7
Pages
1324 - 1334
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