Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers

Reflex immunohistochemistry ( rIHC ) for mismatch repair ( MMR ) protein expression can be used as a screening tool to detect Lynch Syndrome ( LS ). Increasingly the mismatch repair‐deficient ( dMMR ) phenotype has therapeutic implications. We investigated the pattern and consequence of testing for dMMR in three Irish Cancer Centres ( CC s). CRC databases were analyzed from January 2005–December 2013. CC 1 performs IHC upon physician request, CC...