Efficient Monte Carlo Estimation of the Expected Value of Sample Information Using Moment Matching

The Expected Value of Sample Information (EVSI) is used to calculate the economic value of a new research strategy. Although this value would be important to both researchers and funders, there are very few practical applications of the EVSI. This is due to computational difficulties associated with calculating the EVSI in practical health economic models using nested simulations.We present an approximation method for the EVSI that is framed in...