The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

Nature64.80
Volume: 545, Issue: 7652, Pages: 93 - 97
Published: Apr 26, 2017
Abstract
Mitochondrial calcium (mCa2+) has a central role in both metabolic regulation and cell death signalling, however its role in homeostatic function and disease is controversial. Slc8b1 encodes the mitochondrial Na+/Ca2+ exchanger (NCLX), which is proposed to be the primary mechanism for mCa2+ extrusion in excitable cells. Here we show that tamoxifen-induced deletion of Slc8b1 in adult mouse hearts causes sudden death, with less than 13% of...
Paper Details
Title
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.
Published Date
Apr 26, 2017
Journal
Volume
545
Issue
7652
Pages
93 - 97
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