Spermatogenic failure and the Y chromosome
Abstract
The Y chromosome harbors a number of genes essential for testis development and function. Its highly repetitive structure predisposes this chromosome to deletion/duplication events and is responsible for Y-linked copy-number variations (CNVs) with clinical relevance. The AZF deletions remove genes with predicted spermatogenic function en block and are the most frequent known molecular causes of impaired spermatogenesis (5–10% of azoospermic and...
Paper Details
Title
Spermatogenic failure and the Y chromosome
Published Date
Apr 29, 2017
Journal
Volume
136
Issue
5
Pages
637 - 655
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