Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Abstract
Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with a growth advantage in culture. The nature, extent and functional effects of other acquired genome sequence mutations in cultured hPS cells are not known. Here we sequence the protein-coding...
Paper Details
Title
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Published Date
Apr 26, 2017
Journal
Volume
545
Issue
7653
Pages
229 - 233
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