Truncating mutations on myofibrillar myopathies causing genes as prevalent molecular explanations on patients with dilated cardiomyopathy

Dilated cardiomyopathy ( DCM ) is one of the leading causes of heart failure with high morbidity and mortality. More than 40 genes have been reported to cause DCM . To provide new insights into the pathophysiology of dilated cardiomyopathy, a next‐generation sequencing ( NGS ) workflow based on a panel of 48 cardiomyopathies‐causing genes was used to analyze a cohort of 222 DCM patients. Truncating variants were detected on 63 unrelated DCM...