PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
Abstract
Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymerase 3 (PARP3) as promoters of chromosomal...
Paper Details
Title
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
Published Date
Apr 27, 2017
Journal
Volume
8
Issue
1
Pages
15110 - 15110
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History