PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Volume: 8, Issue: 1, Pages: 15110 - 15110
Published: Apr 27, 2017
Abstract
Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymerase 3 (PARP3) as promoters of chromosomal...
Paper Details
Title
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
Published Date
Apr 27, 2017
Volume
8
Issue
1
Pages
15110 - 15110
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