DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients
Abstract
The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) age based on the cumulative assessment of the methylation levels of 353 CpGs included on the genome-wide 450k BeadChip. DNAm age may reflect biological...
Paper Details
Title
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients
Published Date
Apr 24, 2017
Journal
Volume
134
Issue
2
Pages
271 - 279
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