A Tribological Simulator as a Test Platform for Cartilage Injury and Response

Purpose: Post-traumatic initiation of OA has been likened to a “non-healing wound,” causing aberrant repair and structural tissue damage. There are several targeted interventions under development that would benefit from an early screening model that takes the mechanical environment of the joint into account. The purpose of this study was to further evaluate a recently presented model of cartilage shear damage with regard to gene expression and...