New Thomimarine E from Marine Isolate of the Fungus Penicillium thomii

The new eudesmane-type sesquiterpene thomimarine E (1) and the known compounds guaiadiol A (2) and 4,10,11-trihydroxyguaiane (3) were isolated from the marine isolate of the fungus Penicillium thomii. The structures of the compounds were established using NMR spectroscopy and high-resolution mass spectrometry. The ability of all compounds to inhibit production of NO in lipopolysaccharide-stimulated murine macrophages (RAW 264.7 line) at nontoxic...