Chondroitin Sulphate Inhibits Monocyte Chemoattractant Protein-1 Release from 3T3L1 Adipocytes: A New Treatment Opportunity for Obesity-related Metabolic Syndromes?

Purpose: Monocyte chemoattractant protein-1(MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. We have recently published that chondroitin sulphate (CS) can attenuate the MSU crystal mediated THP-1 macrophage inflammatory response reflected by reduced release of pro-inflammatory cytokines IL-1β and TNFα. We have also recently determined that the CS inhibitory effect is not acting at...