Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity
Abstract
Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenetic mechanisms, but also inflammation and cell state reprogramming in creating tumor heterogeneity. We discuss similarities between normal mammary epithelial...
Paper Details
Title
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity
Published Date
Apr 19, 2017
Journal
Volume
3
Issue
1
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