A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis
Abstract
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize the interactome of a multitude of pre-miRNAs. We identify ∼180 RBPs that interact specifically with distinct pre-miRNAs. For functional validation,...
Paper Details
Title
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis
Published Date
Apr 1, 2017
Journal
Volume
66
Issue
2
Pages
270 - 284.e13
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