Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
Abstract
Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice with loss-of-function mutations in Chd8, a de novo mutation strongly associated with ASD, and demonstrate that these mice display hallmark ASD behaviors, macrocephaly, and craniofacial abnormalities similar to patient phenotypes. Chd8+/–...
Paper Details
Title
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
Published Date
Apr 1, 2017
Journal
Volume
19
Issue
2
Pages
335 - 350
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