IP 3 -mediated gating mechanism of the IP 3 receptor revealed by mutagenesis and X-ray crystallography
Volume: 114, Issue: 18, Pages: 4661 - 4666
Published: Apr 17, 2017
Abstract
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is an IP3-gated ion channel that releases calcium ions (Ca2+) from the endoplasmic reticulum. The IP3-binding sites in the large cytosolic domain are distant from the Ca2+ conducting pore, and the allosteric mechanism of how IP3 opens the Ca2+ channel remains elusive. Here, we identify a long-range gating mechanism uncovered by channel mutagenesis and X-ray crystallography of the large...
Paper Details
Title
IP 3 -mediated gating mechanism of the IP 3 receptor revealed by mutagenesis and X-ray crystallography
Published Date
Apr 17, 2017
Volume
114
Issue
18
Pages
4661 - 4666
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