Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Abstract
High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to immune checkpoint inhibitors and has been shown to be more significantly associated with response to PD-1 and PD-L1 blockade immunotherapy than PD-1 or PD-L1 expression, as measured by immunohistochemistry (IHC). The distribution of TMB and the subset of patients with high TMB has not been well characterized in the majority of cancer types.In this study, we compare TMB...
Paper Details
Title
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Published Date
Apr 19, 2017
Journal
Volume
9
Issue
1
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