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Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects

Published on Apr 1, 2017in Physiological Reports
· DOI :10.14814/phy2.13197
Eleonora Tobaldini18
Estimated H-index: 18
(University of Milan),
Naima Covassin11
Estimated H-index: 11
(Mayo Clinic)
+ 5 AuthorsVirend K. Somers93
Estimated H-index: 93
(Mayo Clinic)
Abstract
Abstract Acute sleep deprivation (SD) alters cardiovascular autonomic control (CAC) and is associated with an increased risk of cardiovascular disorders. However, the effects of partial SD on CAC are unclear. Thus, we aimed to investigate the effects of partial SD on CAC during sleep. We randomized seventeen healthy subjects to a restriction group (RES, n  = 8, subjects slept two‐thirds of normal sleep time based on individual habitual sleep duration for 8 days and 8 nights) or a Control group (CON, n  = 9, subjects were allowed to sleep their usual sleep time). Attended polysomnographic (PSG) studies were performed every night; a subset of them was selected for the analysis at baseline (day 3‐D3), the first night after sleep restriction (day 5‐D5), at the end of sleep restriction period (day 11‐D11), and at the end of recovery phase (day 14‐D14). We extracted electrocardiogram (ECG) and respiration from the PSG and divided into wakefulness (W), nonrapid eye movements (REM) sleep (N2 and N3) and REM sleep. CAC was evaluated by means of linear spectral analysis, nonlinear symbolic analysis and complexity indexes. In both RES and CON groups, sympathetic modulation decreased and parasympathetic modulation increased during N2 and N3 compared to W and REM at D3, D5, D11, D14. Complexity analysis revealed a reduction in complexity during REM compared to NREM sleep in both DEP and CON. After 8 days of moderate SD, cardiac autonomic dynamics, characterized by decreased sympathetic, and increased parasympathetic modulation, and higher cardiac complexity during NREM sleep, compared to W and REM, are preserved.
  • References (28)
  • Citations (4)
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References28
Newest
#1Fabien Sauvet (Paris V: Paris Descartes University)H-Index: 13
#2Catherine Drogou (Paris V: Paris Descartes University)H-Index: 19
Last. Mounir Chennaoui (Paris V: Paris Descartes University)H-Index: 23
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Abstract Background Sleep loss may induce endothelial dysfunction, a key factor in cardiovascular risk. We examined the endothelial function during one week of sleep restriction and a recovery period (from 3-to-13 days) in healthy subjects, and its link to autonomic, inflammatory and/or endocrine responses. Methods 12 men were followed at baseline (B1, 8-h sleep), after 2 (SR2) and 6 (SR6) days of SR (4-h sleep: 02:00–06:00) and after 1 (R1) and 12 (R12) recovery nights (8 h sleep). At 10:00, we...
19 CitationsSource
#1Eleonora Tobaldini (University of Milan)H-Index: 18
#2Paola ProserpioH-Index: 13
Last. Nicola Montano (University of Milan)H-Index: 47
view all 12 authors...
Abstract Background Spinal cord injuries (SCI) are associated with altered cardiovascular autonomic control (CAC). Sleep is characterized by modifications of autonomic control across sleep stages; however, no data are available in SCI subjects on CAC during sleep. We aim to assess cardiac autonomic modulation during sleep in subjects with SCI. Patients and methods 27 participants with a neurological and radiological diagnosis of cervical (Cerv, n = 12, ie, tetraplegic) and thoracic SCI (Thor, n ...
6 CitationsSource
#1Andrew D. Calvin (Mayo Clinic)H-Index: 14
#2Naima Covassin (Mayo Clinic)H-Index: 11
Last. Virend K. Somers (Mayo Clinic)H-Index: 93
view all 12 authors...
Background Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of heightened cardiovascular risk. We sought to determine the effect of 8 days/8 nights of partial sleep restriction on endothelial function in healthy humans. Methods and Resul...
42 CitationsSource
#1Murat Sunbul (Marmara University)H-Index: 12
#2Batur Gonenc Kanar (Marmara University)H-Index: 3
Last. Ibrahim Sari (Marmara University)H-Index: 21
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36 CitationsSource
#1Fabien SauvetH-Index: 13
#2G. FlorenceH-Index: 8
Last. Mounir ChennaouiH-Index: 23
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#1Vincenzo Patruno (University of Milan)H-Index: 4
#2Eleonora Tobaldini (University of Milan)H-Index: 18
Last. Nicola Montano (University of Milan)H-Index: 47
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17 CitationsSource
#1Thomas E. Dick (Case Western Reserve University)H-Index: 34
#2Yee Hsee Hsieh (Case Western Reserve University)H-Index: 9
Last. Kendall F. Morris (USF: University of South Florida)H-Index: 31
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Cardiorespiratory coupling is an encompassing term describing more than the well-recognized influences of respiration on heart rate and blood pressure. Our data indicate that cardiorespiratory coupling reflects a reciprocal interaction between autonomic and respiratory control systems, and the cardiovascular system modulates the ventilatory pattern as well. For example, cardioventilatory coupling refers to the influence of heart beats and arterial pulse pressure on respiration and is the tendenc...
36 CitationsSource
#1Eleonora Tobaldini (University of Milan)H-Index: 18
#2Marica PecisH-Index: 12
Last. Nicola Montano (University of Milan)H-Index: 47
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Sleep is a fundamental physiological process, characterized by the activation of several cortical and subcortical neural networks. The relation between sleep and cardiovascular system is complex and bidirectional: sleep disor- ders may alter cardiovascular system, leading to an increased cardiovascular risk, while, on the contrary, cardio- vascular diseases are characterized by an alteration of physiological sleep. Autonomic nervous system (ANS) plays a key role in the regulation of cardiovascul...
14 CitationsSource
#1Jae Seung Chang (Seoul National University Bundang Hospital)H-Index: 14
#2Sang Don Lee (Seoul National University Bundang Hospital)H-Index: 9
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Abstract Background Weak cardiorespiratory coupling (CRC) has been suggested in patients with obstructive sleep apnea (OSA), but the effects of continuous positive airway pressure (CPAP) on CRC remain unclear. We investigated the effects of CPAP treatment on CRC in patients with severe OSA to examine possible reversibility of altered CRC. Methods High-resolution electrocardiograms (ECGs) and respiratory signals were simultaneously recorded for 13 never-treated OSA patients at baseline and after ...
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#1Eleonora Tobaldini (University of Milan)H-Index: 18
#2Lino NobiliH-Index: 45
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Sleep is a physiological process involving different biological systems, from molecular to organ level; its integrity is essential for maintaining health and homeostasis in human beings. Although in the past sleep has been considered a state of quiet, experimental and clinical evidences suggest a noteworthy activation of different biological systems during sleep. A key role is played by the autonomic nervous system (ANS), whose modulation regulates cardiovascular functions during sleep onset and...
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The purpose of this study was to investigate the effects of chronic rapid eye movement sleep deprivation on cardiovascular system using blood levels of lipocalin-2, nitric oxide synthase-3, interleukin-6, and cardiotrophin-1. We included sixteen Wistar Albino rats of 300–350 g weight in the study. To create a chronic rapid eye movement sleep deprivation, we used water tanks with platform including modified multiple sleep deprivation platforms, and we used water tanks with grid to grab for contro...
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