Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Abstract
Recent studies have revealed that newly emerging transformed cells are often apically extruded from epithelial tissues. During this process, normal epithelial cells can recognize and actively eliminate transformed cells, a process called epithelial defence against cancer (EDAC). Here, we show that mitochondrial membrane potential is diminished in RasV12-transformed cells when they are surrounded by normal cells. In addition, glucose uptake is...
Paper Details
Title
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Published Date
Apr 17, 2017
Journal
Volume
19
Issue
5
Pages
530 - 541
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