009 B10 cells suppress contact dermatitis in an antigen specific manner

B cells secrete antigen-specific antibodies during immune responses to neutralize pathogens and foreign antigens. Despite this well-characterized pro-inflammatory B cell function, a rare B cell subset (B10 cells) negatively regulates inflammation and autoimmunity by producing the inhibitory cytokine interleukin (IL)-10. It has been reported that B10 cells have suppressive effects on autoimmune diseases in mouse models. Nonetheless, therapeutic...