Resident memory T cells in the skin mediate durable immunity to melanoma
Abstract
Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment...
Paper Details
Title
Resident memory T cells in the skin mediate durable immunity to melanoma
Published Date
Apr 21, 2017
Journal
Volume
2
Issue
10
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