Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans

Although green tea ( Camellia sinensis) ( GT ) contains a large number of polyphenolic compounds with anti‐oxidative and anti‐proliferative activities, little is known of the pharmacokinetics and tissue dose of tea catechins ( TC s) as a chemical mixture in humans. The objectives of this study were to develop and validate a physiologically based pharmacokinetic ( PBPK ) model of tea catechin mixture ( TCM ) in rats and humans, and to predict an...