Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers
Abstract
Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target nearly all cyclins/CDKs, which are very effective in inhibiting cancer cell proliferation. By profiling the response of over 120 human cancer cell...
Paper Details
Title
Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers
Published Date
Apr 1, 2017
Journal
Volume
31
Issue
4
Pages
576 - 590.e8
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