Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions

Volume: 25, Issue: 4, Pages: 954 - 960
Published: Apr 4, 2017
Abstract
Summary null The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles. The resulting clock correctly determines the age of mouse cohorts, detects the longevity effects of calorie restriction and gene knockouts, and reports rejuvenation of fibroblast-derived iPSCs. The data...
Paper Details
Title
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions
Published Date
Apr 4, 2017
Volume
25
Issue
4
Pages
954 - 960
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