Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?
Published on Oct 1, 2017in Journal of Cancer Research and Clinical Oncology3.33
· DOI :10.1007/s00432-017-2418-2
Introduction Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. In the past few years, the discovery of inter-genomic crosstalk between nucleus and mitochondria has reinforced the role of mitochondrial DNA variants in perturbing this essential signaling pathway and thus indirectly targeting nuclear genes involved in tumorigenic and invasive phenotype.