Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

Objective To determine the ability of drugs that activate inhibitory G protein–coupled receptors (GPCRs) expressed in peripheral voltage‐gated sodium channel 1.8 (Na V 1.8)–positive sensory neurons to control osteoarthritis (OA)–associated pain. Methods We used designer receptors exclusively activated by a designer drug (DREADD) technology, which employs engineered GPCRs to activate or inhibit neurons upon binding the synthetic ligand clozapine...