Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment
Abstract
Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU-acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome...
Paper Details
Title
Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment
Published Date
May 3, 2017
Journal
Volume
222
Issue
1
Pages
e12885 - e12885
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