Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
Abstract
The mechanosensitive two-pore domain (K2P) K+ channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the “down” to “up” conformation in direct response to membrane stretch, and examine the role of the...
Paper Details
Title
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
Published Date
May 1, 2017
Journal
Volume
25
Issue
5
Pages
708 - 718.e2
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History