Nanoencapsulation of Insulin Using Blends of Biodegradable Polymers and In Vitro Controlled Release of Insulin

The purpose of this study was achieving an optimum formulation with low initial burst and steady-state release of insulin from the nanoparticles prepared with different blends of poly(lactide-co-glycolide) (PLGA), polylactic acid (PLA), poly(e-caprolactone) (PCL) and Eudragit® RS100 polymers. Insulin was encapsulated in different blends of these polymers using W/O/W double emulsion technique. Methylene chloride was used as the organic solvent...