p53 and its mutants on the slippery road from stemness to carcinogenesis
Abstract
Normal development, tissue homeostasis and regeneration following injury rely on the proper functions of wide repertoire of stem cells (SCs) persisting during embryonic period and throughout the adult life. Therefore, SCs employ robust mechanisms to preserve their genomic integrity and avoid heritage of mutations to their daughter cells. Importantly, propagation of SCs with faulty DNA as well as dedifferentiation of genomically altered somatic...
Paper Details
Title
p53 and its mutants on the slippery road from stemness to carcinogenesis
Published Date
Mar 15, 2017
Journal
Volume
38
Issue
4
Pages
347 - 358
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