The role of metabolism in the pathogenesis of osteoarthritis
Abstract
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors...
Paper Details
Title
The role of metabolism in the pathogenesis of osteoarthritis
Published Date
May 1, 2017
Journal
Volume
13
Issue
5
Pages
302 - 311
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Notes
History