Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis
Abstract
By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains unclear. Our data suggests that no common mtDNA mutation identifies metastatic cells; rather the metastatic potential of several ROS-generating...
Paper Details
Title
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis
Published Date
Apr 3, 2017
Journal
Volume
36
Issue
31
Pages
4393 - 4404
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Notes
History