Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase

Published on Mar 1, 2017in Cell Death and Disease5.959
路 DOI :10.1038/cddis.2017.116
Hyung Chul Lee11
Estimated H-index: 11
(IIT: Inha University),
Nam Gu Her6
Estimated H-index: 6
(KU: Korea University)
+ 8 AuthorsJae Seon Lee20
Estimated H-index: 20
(IIT: Inha University)
Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
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Summary The PDZ-binding kinase/T-LAK cell鈥搊riginated protein kinase (PBK/TOPK) is highly expressed in many types of tumors. However, its role in lung adenocarcinoma remains elusive. The aims of this study were to investigate the correlation between PBK/TOPK and mutant p53 in lung adenocarcinoma and to evaluate the effect of PBK/TOPK on cell proliferation and viability. Expression of PBK/TOPK and mutant p53 was detected in 127 cases of lung adenocarcinoma and was examined in the A549, GLC-82, and...
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MiR-34a, an important tumor-suppressing microRNA, is downregulated in several types of cancer; loss of its expression has been linked with unfavorable clinical outcomes in non-small-cell lung cancer (NSCLC), among others. MiR-34a represses several key oncogenic proteins, and a synthetic mimic of miR-34a is currently being tested in a cancer trial. However, little is known about the potential role of miR-34a in regulating DNA damage response and repair. Here, we demonstrate that miR-34a directly ...
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