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Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase

Published on Mar 1, 2017in Cell Death and Disease5.959
路 DOI :10.1038/cddis.2017.116
Hyung Chul Lee11
Estimated H-index: 11
(IIT: Inha University),
Nam Gu Her6
Estimated H-index: 6
(KU: Korea University)
+ 8 AuthorsJae Seon Lee20
Estimated H-index: 20
(IIT: Inha University)
Abstract
Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
  • References (37)
  • Citations (7)
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#1Henan ZhaoH-Index: 5
#2Xiaotang YuH-Index: 3
Last. Shiying CuiH-Index: 6
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// Henan Zhao 1 , Xiaotang Yu 1 , Yanfang Ding 1 , Jinyao Zhao 1 , Guang Wang 1 , Xian Wu 1 , Jiyong Jiang 2 , Chun Peng 3 , Gordon Zhuo Guo 4 , Shiying Cui 1 1 Dalian Medical University, Dalian, China 2 Obstetrics and Gynecology Hospital, Dalian, China 3 Department of Biology, York University, Toronto, Canada 4 Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA Correspondence to: Shiying Cui, email: scui2003@dlmedu.edu.cn , 2501532244@qq.com Gordon Zh...
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#1Mrinal Joel (University of Oslo)H-Index: 10
#2Awais A. Mughal (Oslo University Hospital)H-Index: 5
Last. Biljana Stangeland (Oslo University Hospital)H-Index: 11
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Background Glioblastomas are invasive therapy resistant brain tumors with extremely poor prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance and tumor recurrence. Targeting GIC-associated gene candidates could significantly impact GBM tumorigenicity. Here, we investigate a protein kinase, PBK/TOPK as a candidate for regulating growth, survival and in vivo tumorigenicity of GICs.
31 CitationsSource
The aim of this study is to describe the biogenesis of microRNA, its relations with carcinogenesis, and the correlation between microRNA and ionizing radiation (IR), focusing on radioresponsiveness. It is known that microRNA biogenesis is well established and involves different enzymatic cleavages, resulting in the production of mature microRNA. MicroRNAs are involved in carcinogenesis. Their interaction is related to the genetic and epigenetic changes associated with activation of proto-oncogen...
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#1Bin Lei (Southern Medical University)H-Index: 5
#2Wenjuan Qi (Southern Medical University)H-Index: 4
Last. Hong Shen (Southern Medical University)H-Index: 3
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Summary The PDZ-binding kinase/T-LAK cell鈥搊riginated protein kinase (PBK/TOPK) is highly expressed in many types of tumors. However, its role in lung adenocarcinoma remains elusive. The aims of this study were to investigate the correlation between PBK/TOPK and mutant p53 in lung adenocarcinoma and to evaluate the effect of PBK/TOPK on cell proliferation and viability. Expression of PBK/TOPK and mutant p53 was detected in 127 cases of lung adenocarcinoma and was examined in the A549, GLC-82, and...
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#1Maria Angelica Abdalla Cortez (University of Texas MD Anderson Cancer Center)H-Index: 19
#2David Valdecanas (University of Texas MD Anderson Cancer Center)H-Index: 15
Last. James Welsh (University of Texas MD Anderson Cancer Center)H-Index: 34
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MiR-34a, an important tumor-suppressing microRNA, is downregulated in several types of cancer; loss of its expression has been linked with unfavorable clinical outcomes in non-small-cell lung cancer (NSCLC), among others. MiR-34a represses several key oncogenic proteins, and a synthetic mimic of miR-34a is currently being tested in a cancer trial. However, little is known about the potential role of miR-34a in regulating DNA damage response and repair. Here, we demonstrate that miR-34a directly ...
24 CitationsSource
#1Aihong MaoH-Index: 8
#2Yang LiuH-Index: 11
Last. Chao SunH-Index: 13
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Increasing evidence demonstrates that the expression levels of microRNAs (miRNAs) significantly change upon ionizing radiation (IR) and play a critical role in cellular response to IR. Although several radiation responsive miRNAs and their targets have been identified, little is known about how miRNAs expression and biogenesis is regulated by IR-caused DNA damage response (DDR). Hence, in this review, we summarize miRNA expression and biogenesis in cellular response to IR and mainly elucidate th...
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#1Paolo GandelliniH-Index: 22
#2Tiziana RancatiH-Index: 23
Last. Nadia ZaffaroniH-Index: 46
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There is increasing interest in defining a functional association between miRNAs and tumor radiation response, with the double aim of rationally designing miRNA-based strategies to increase patient radiosensitivity and identifying novel biomarkers of treatment response. Although it has been demonstrated that several miRNAs directly regulate the expression of components of cell pathways relevant to radiosensitivity, and miRNA expression profiles change upon irradiation, understanding the causal r...
15 CitationsSource
Abstract Significance: microRNAs (miRNA) have been characterized as master regulators of the genome. As such, miRNAs are responsible for regulating almost every cellular pathway, including the DNA damage response (DDR) after ionizing radiation (IR). IR is a therapeutic tool that is used for the treatment of several types of cancer, yet the mechanism behind radiation response is not fully understood. Recent Advances: It has been demonstrated that IR can alter miRNA expression profiles, varying gr...
30 CitationsSource
#1Jinwook Shin (Duke University)H-Index: 18
#2Danli Xie (WMU: Wenzhou Medical College)H-Index: 7
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
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The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKC胃/NF魏B pathways. DAG kinases (DGKs) participate in the metabolism of DAG by converting it to phosphatidic acid. DGK味 has been demonstrated to be able to inhibit DAG signaling following TCR engagement. Deficiency of DGK味 increases the sensitivity of T cells to TCR stimulation, resulting in enhanced T cell activation ex vivo and in vivo. Howev...
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#1Bin Lei (Southern Medical University)H-Index: 5
#2Shuguang Liu (Southern Medical University)H-Index: 5
Last. Hong Shen (Southern Medical University)H-Index: 3
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Aims The aim of this study was to evaluate the prevalence of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) expression, and explore the prognostic significance of PBK/TOPK expression alone and in combination with Ki67 and p53 expression in non-small-cell lung cancer (NSCLC). Methods and results We detected PBK/TOPK expression in 30 samples of normal lung tissue, 32 lymph node metastases and 279 primary non-small-cell lung cancers by immunohistochemistry, and analysed the corr...
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Cited By7
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#1Lei Jia (HMU: Harbin Medical University)
#2Yuwen Song (HMU: Harbin Medical University)H-Index: 2
Last. Wenjuan Meng (HMU: Harbin Medical University)
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Through the microarray analysis, long noncoding RNA TPT1-AS1 (TPT1-AS1) was identified in the development of glioma. However, the specific effect of TPT1-AS1 on glioma autophagy in the recent years has not fully been investigated. Therefore, the purpose of our present study is to investigate the function of TPT1-AS1 on affecting autophagy of glioma cells through regulation of microRNA-770-5p (miR-770-5p)-mediated stathmin 1 (STMN1). Initially, the expression of TPT1-AS1, miR-770-5p, and STMN1 we...
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#1Hanlin Ma (SDU: Shandong University)H-Index: 1
#2Yingwei Li (SDU: Shandong University)H-Index: 5
Last. Beihua Kong (SDU: Shandong University)H-Index: 23
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High-grade serous ovarian carcinoma (HGSOC) is the most lethal type of gynecologic malignancy. Chemoresistance is the main reason for the poor prognosis of HGSOC. PDZ-binding kinase (PBK) promotes the malignant progression of various carcinomas. However, the roles and clinical significance of PBK in HGSOC remain unclear. Here, we reported that PBK was overexpressed in HGSOC tissues and cell lines. High PBK expression was associated with a poor prognosis, metastasis, and cisplatin resistance of H...
5 CitationsSource
#1Zhe Wang (DUT: Dalian University of Technology)
#2Ji鈥怶ei Mao (DUT: Dalian University of Technology)
Last. Ruoyu Wang (DUT: Dalian University of Technology)H-Index: 4
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#2Ruchi Jain (IISc: Indian Institute of Science)H-Index: 7
Last. Vani SantoshH-Index: 27
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Purpose Peritumoural brain zone (PT) of glioblastoma (GBM) is the area where tumour recurrence is often observed. We aimed to identify differentially regulated genes between tumour core (TC) and PT to understand the underlying molecular characteristics of infiltrating tumour cells in PT.
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#1Yaming Li (SDU: Shandong University)H-Index: 10
#2Yiran Liang (SDU: Shandong University)H-Index: 3
Last. Qifeng Yang (SDU: Shandong University)H-Index: 36
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Chemo-resistance and metastasis of triple negative breast cancer (TNBC) contributed the most of treatment failure in the clinic. MicroRNAs (miRNAs) have been proved to be involved in many biological processes and diseases. In this study, we aimed to determine the role of miR-770 in the regulation of chemo-resistance and metastasis of TNBC. Clinically, miR-770 was highly expressed in chemo-sensitive tissues and predicted a better prognosis of TNBC. Functionally, ectopic expression of miR-770 supp...
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#1Zhi-Wei ZhangH-Index: 1
#2Yang YangH-Index: 1
Last. Xiu-Qiang ZhangH-Index: 1
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Abstract Aims MicroRNAs (miRNAs) plays important role in development and disease, especially in cancer including non-small cell lung cancer (NSCLC). However, the role of miR-770 in NSCLC remains unclear. In this study, we aimed to study the function and mechanism of miR-770 in tumorigenesis of NSCLC. Main methods RT-qPCR was used to measure the expression levels of miR-770 in NSCLC tissues and cells. MTT assay, colony formation assay, flow cytometric analysis and transwell migration and invasion...
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