Original paper
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Abstract
Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that key features of disease correlated inversely with blood and fecal concentrations of the microbial metabolites acetate and butyrate. We therefore fed NOD mice specialized diets designed to release large amounts of acetate or butyrate after bacterial fermentation in the colon. Each diet provided a high degree of...
Paper Details
Title
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Published Date
Mar 27, 2017
Journal
Volume
18
Issue
5
Pages
552 - 562
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Notes
History