Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy.

Volume: 98, Issue: 5, Pages: 1183 - 1196
Published: Aug 1, 2017
Abstract
With the increasing incidence of cancer worldwide, the need for specific, effective therapies is ever more urgent. One example of targeted cancer therapeutics is hypoxia-activated prodrugs (HAPs), also known as bioreductive prodrugs. These prodrugs are inactive in cells with normal oxygen levels but in hypoxic cells (with low oxygen levels) undergo chemical reduction to the active compound. Hypoxia is a common feature of solid tumors and is...
Paper Details
Title
Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy.
Published Date
Aug 1, 2017
Volume
98
Issue
5
Pages
1183 - 1196
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