Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Abstract
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity supports critical developmental trajectories, sensory and cognitive processing, and social behavior. Despite heterogeneity in the etiology across schizophrenia and autism spectrum disorder, PVI circuits are altered in these psychiatric disorders. Identifying mechanism(s)...
Paper Details
Title
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Published Date
Mar 21, 2017
Journal
Volume
22
Issue
7
Pages
936 - 943
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Notes
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