A Phase Separation Model for Transcriptional Control
Abstract
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an...
Paper Details
Title
A Phase Separation Model for Transcriptional Control
Published Date
Mar 1, 2017
Journal
Volume
169
Issue
1
Pages
13 - 23
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