Engineering efficient production of itaconic acid from diverse substrates in Escherichia coli

Volume: 249, Pages: 73 - 81
Published: May 1, 2017
Abstract
Itaconic acid is an excellent polymeric precursor with wide range of industrial applications. Here, efficient production of itaconate from various renewable substrates was demonstrated by engineered Escherichia coli. Limitation in the itaconate precursor supply was revealed by feeding of the key intermediate citrate to the culture medium. Efforts of enhancing the cis-aconitate flux and preserving the isocitrate pool increased itaconate...
Paper Details
Title
Engineering efficient production of itaconic acid from diverse substrates in Escherichia coli
Published Date
May 1, 2017
Volume
249
Pages
73 - 81
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