pH-responsive drug release and real-time fluorescence detection of porous silica nanoparticles

Published on Aug 1, 2017in Materials Science and Engineering: C4.959
· DOI :10.1016/j.msec.2017.03.224
Xu Zhang4
Estimated H-index: 4
(Henan University),
Yamin Wang1
Estimated H-index: 1
+ 1 AuthorsLei Sun11
Estimated H-index: 11
(Henan University)
Abstract In this work, pH-sensitive “dual-switch” porous silica (pSiO2) nanoparticles (NPs) were constructed for drug delivery. Poly(acrylic acid) (PAA) was grafting onto the internal and external surfaces of amino groups functionalized porous silica (pSiO2-NH2) NPs by the amidation between the amino groups and the carboxyl groups of PAA for pH triggered drug release. The resultant pSiO2/PAA NPs have an average diameter of 50–60 nm and high specific surface area (914 m2·g− 1). To improve the loading capacity, ZnO quantum dots (QDs) were used to block the partial pores of pSiO2/PAA and the loading capacity reached to 28% for methotrexate (MTX) model drug. The in vitro cellular cytotoxicity test and a hemolysis assay demonstrated that the pSiO2/PAA/ZnO NPs were highly biocompatible and suitable to utilize as drug carriers. The MTX-loaded pSiO2/PAA/ZnO NPs displayed more efficient cytotoxic to HepG2 cells than free MTX. The pSiO2/PAA/ZnO NPs displayed low premature, pH-responsive release and pH-dependent fluorescence. Moreover, pH-dependent fluorescence enables to trace MTX release behavior.
  • References (13)
  • Citations (6)
📖 Papers frequently viewed together
1 Citations
6 Citations
5 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Xu Zhang (Henan University)H-Index: 4
#2Yanbao Zhao (Henan University)H-Index: 14
Last. Lei Sun (Henan University)H-Index: 11
view all 4 authors...
5 CitationsSource
#1S.A. Gârea (Politehnica University of Bucharest)H-Index: 2
#2A.I. Mihai (Politehnica University of Bucharest)H-Index: 2
Last. Raul-Augustin Mitran (Romanian Academy)H-Index: 8
view all 6 authors...
Abstract The effect of co-surfactant type on the properties of porous clay heterostructures (PCH) was investigated by using FTIR, TGA, XRD, TEM and nitrogen adsorption-desorption isotherms. Two commercial polyetheramines (B100 and B200) with different structures and hydrophilic-lipophilic balance (HLB) values were proposed as new co-surfactants for the synthesis of PCH. Textural properties characterization suggested that the PCH samples exhibit higher values of specific surface area (420–655 m2/...
5 CitationsSource
#2Guillaume MonierH-Index: 10
Last. B. GruzzaH-Index: 15
view all 9 authors...
This study reports a synthesis by the sol–gel method of stable and size-controlled ZnO quantum dots (QDs) embedded into a SiO2 matrix in the diameter range of 2.7–5.5 nm with strong visible emission in the blue-green region. X-ray diffraction and selected area electron diffraction techniques evidence a wurtzite structure of the prepared ZnO QDs. Transmission electron microscopy investigation highlights that the ZnO nanoparticles produced in methanol solution have a nonuniform shape. Addition of ...
27 CitationsSource
#1Manju Kanamala (University of Auckland)H-Index: 4
#2William R. Wilson (University of Auckland)H-Index: 49
Last. Zimei Wu (University of Auckland)H-Index: 19
view all 5 authors...
Abstract As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new strategy for addressing the limitations of the conventional chemotherapy. In the last decade, the volume of research published in this area has increased tremendously, especially with functional nano drug delivery systems (nanocarriers). Couplin...
251 CitationsSource
#1Thomas Swift (University of Sheffield)H-Index: 6
#2Linda Swanson (University of Sheffield)H-Index: 24
Last. Stephen Rimmer (University of Sheffield)H-Index: 26
view all 4 authors...
Fluorescence spectroscopy on a series of aqueous solutions of poly(acrylic acid) containing a luminescent label showed that polymers with molar mass, Mn < 16.5 kDa did not exhibit a pH responsive conformational change, which is typical of higher molar mass poly(acrylic acid). Below this molar mass, polymers remained in an extended conformation, regardless of pH. Above this molar mass, a pH-dependent conformational change was observed. Diffusion-ordered nuclear magnetic resonance spectroscopy con...
83 CitationsSource
#1Na Cao (Henan University)H-Index: 5
#2Miao Li (Henan University)H-Index: 1
Last. Lei Sun (Henan University)H-Index: 11
view all 7 authors...
Abstract To create novel nanocarriers for achieving excellent drug delivery performance, pH-responsive fluorescent porous silica (PS) nanocarriers were developed by encapsulating SnO 2 nanoparticles and coating polyethyleneimine (PEI) layer. SnO 2 /porous silica (SnO 2 /PS) nanoparticles have an average diameter of 80 nm and center-radial large pore channels. The large channels endow them high surface area with a Brunauer–Emmett–Teller (BET) area of 939 m 2 g − 1 . Aspirin was used as test drug ...
14 CitationsSource
#1Xuan Wu (NU: Nanjing University)H-Index: 11
#2Yan Li (SEU: Southeast University)H-Index: 8
Last. Leyong Wang (NU: Nanjing University)H-Index: 39
view all 5 authors...
Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated acidic tumor environment with high GSH concentration, and exhibit potent antitumor activity.
77 CitationsSource
A novel type of cellular-uptake-shielding multifunctional envelope-type mesoporous silica nanoparticle (MEMSN) was designed for tumor-triggered targeting drug delivery to cancerous cells. β-Cyclodextrin (β-CD) was anchored on the surface of mesoporous silica nanoparticles via disulfide linking for glutathione-induced intracellular drug release. Then a peptide sequence containing Arg-Gly-Asp (RGD) motif and matrix metalloproteinase (MMP) substrate peptide Pro-Leu-Gly-Val-Arg (PLGVR) was introduce...
313 CitationsSource
#1Diana Kozlova (University of Duisburg-Essen)H-Index: 11
#2Svitlana Chernousova (University of Duisburg-Essen)H-Index: 11
Last. Matthias Epple (University of Duisburg-Essen)H-Index: 55
view all 6 authors...
Calcium phosphate nanoparticles were coated with a shell of silica and covalently functionalized by silanization, either with thiol or with amino groups. This permits the covalent attachment of molecules like dyes or antibodies. Between the calcium phosphate surface and the outer silica shell, biomolecules like nucleic acids (DNA or siRNA) can be incorporated as cargo. This leads to cell-specific carriers of biomolecules into cells, e.g. for transfection, gene silencing or cell activation. The c...
58 CitationsSource
Acid-decomposable, luminescent ZnO quantum dots (QDs) have been employed to seal the nanopores of mesoporous silica nanoparticles (MSNs) in order to inhibit premature drug (doxorubicin) release. After internalization into HeLa cells, the ZnO QD lids are rapidly dissolved in the acidic intracellular compartments, and as a result, the loaded drug is released into the cytosol from the MSNs. The ZnO QDs behave as a dual-purpose entity that not only acts as a lid but also has a synergistic antitumor ...
373 CitationsSource
Cited By6
Abstract The natural biodegradabilty of porous silicon (pSi) in physiological media limits its wider usage for implantable systems. We report the stabilization of porous silicon (pSi) membranes by chemical surface oxidation using RCA1 and RCA2 protocols, which was followed by a PEGylation process using a silane-PEG. These surface modifications stabilized the pSi to allow a long period of immersion in PBS, while leaving the pSi surface sufficiently hydrophilic for good filtration and diffusion of...
1 CitationsSource
#1Yunyun Chen (Henan University)
#2Yanbao Zhao (Henan University)H-Index: 14
Last. Xueyan Zou (Henan University)H-Index: 7
view all 4 authors...
A multifunctional nanoplatform (pSiO2–Au/HA) combining porous silica (pSiO2) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m2·g−1). Au NPs as photothermal agents and gatekeepers were linked to pSiO2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surfa...
#1Xinli Li (Henan University)
#2Xu Zhang (Henan University)H-Index: 4
Last. Lei Sun (Henan University)H-Index: 11
view all 4 authors...
Abstract Mn-doped mesoporous silica (MMS) nanocarriers were prepared by in situ doping Mn component for drug delivery. In the acidic or reductive microenvironment of tumor, the Mn O bond can be broken up, and Mn components would be released from the silica framework, thus accelerating the degradation of the silica nanocarrier. Due to the mesoporous structure, MMS nanocarriers have a high specific surface area of 1125.56 m2/g, which is suitable for loading and controlled release of drug. And the ...
#1Qianqian Zhang (Henan University)H-Index: 1
#2Jia Guo (Henan University)H-Index: 1
Last. Lei Sun (Henan University)H-Index: 11
view all 6 authors...
4 CitationsSource
#1Raquel O. Rodrigues (University of Porto)H-Index: 8
#2Giovanni BaldiH-Index: 18
Last. Adrián M.T. Silva (University of Porto)H-Index: 43
view all 12 authors...
Abstract The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/...
7 CitationsSource
#1Xu ZhangH-Index: 4
#2Yanbao ZhaoH-Index: 14
Last. Lei SunH-Index: 11
view all 4 authors...
6 CitationsSource
#1Yiming Xiang (Huda: Hubei University)H-Index: 4
#2Xinmei LiuH-Index: 1
Last. Shuilin Wu (Huda: Hubei University)H-Index: 38
view all 9 authors...
Abstract Bacterial infections and related complications are predominantly responsible for the failure of artificial biomaterials assisted tissue regeneration in clinic. In this work, a hybrid surface system is applied to prolong the drug release duration from dug-loaded titania nanotubes and thus to prevent Ti implants-associated bacterial infections. This feature is endowed by conjugating folic acid (FA) onto the surface of ZnO quantum dots (QDs)-NH2 via an amidation reaction. Titania nanotubes...
13 CitationsSource
#1Xiao HuangH-Index: 2
#2Xi ZhengH-Index: 2
Last. Caixia YiH-Index: 2
view all 4 authors...
Abstract Due to the excellent biocompatibility as well as the low cost, nanoscale ZnO shows a great potential in drug delivery application. The richness of the structures, easy modification and pleasant properties of nanoscale ZnO make these materials reasonable choices for drug delivery. In the recent decade, various ZnO nanostructures as well as nanohybrids have been carried out for optimizational drug loading and carrying. To control the drug release behavior, many nanoscale ZnO-based smart d...
13 CitationsSource