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Advancing clinical research by semantically interconnecting aggregated medical data information in a secure context

Published on Nov 1, 2017in Health technology
· DOI :10.1007/s12553-017-0188-0
Athos Antoniades6
Estimated H-index: 6
(University of Cyprus),
Aristos Aristodimou3
Estimated H-index: 3
(University of Cyprus)
+ 15 AuthorsConstantinos S. Pattichis34
Estimated H-index: 34
(University of Cyprus)
Abstract
Electronic Health Records (EHRs) contain an increasing wealth of medical information. When combined with molecular level data, they enhance the understanding of the underlying biological mechanisms of diseases, enabling the identification of key prognostic biomarkers to disease and treatment outcomes. However, the European healthcare information space is fragmented due to the lack of legal and technical standards, cost effective platforms, and sustainable business models. There is a clear need for a framework facilitating the efficient and homogenized access to anonymized distributed EHRs, merged from multiple data sources into a single data analysis space. In this paper we present the outcomes of Linked2Safety, a project that proposes a solution to these problems by providing a semantically interconnected approach to sharing aggregate data in the form of data cubes. This approach eliminates the risks associated with sharing pseudoanonymized (and therefore still personal) data while enabling the multi-source, multi-type analysis of health data through a single web based secure access platform. The Linked2Safety system is evaluated by external to the project Medical science analysts, Analytic methodology engineers and Data providers with respect to five specific dimensions of the system (analysis space, linked data space, usability of the system, legal and ethical issues, and value of the system) in this paper. For all five dimensions that were examined, the participants’ perceptions were overwhelmingly positive.
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Published on Dec 1, 2017in Journal of Biomedical Semantics 1.60
Yasar Khan4
Estimated H-index: 4
(National University of Ireland, Galway),
Muhammad Saleem11
Estimated H-index: 11
(Leipzig University)
+ 4 AuthorsRatnesh Sahay6
Estimated H-index: 6
(National University of Ireland, Galway)
Background Several query federation engines have been proposed for accessing public Linked Open Data sources. However, in many domains, resources are sensitive and access to these resources is tightly controlled by stakeholders; consequently, privacy is a major concern when federating queries over such datasets. In the Healthcare and Life Sciences (HCLS) domain real-world datasets contain sensitive statistical information: strict ownership is granted to individuals working in hospitals, research...
7 Citations Source Cite
Published on Aug 1, 2014in Journal of Biomedical Informatics 2.88
Eleni Kamateri7
Estimated H-index: 7
(University of Macedonia),
Evangelos Kalampokis12
Estimated H-index: 12
(University of Macedonia)
+ 1 AuthorsKonstantinos A. Tarabanis28
Estimated H-index: 28
(University of Macedonia)
Abstract The integration of medical data coming from multiple sources is important in clinical research. Amongst others, it enables the discovery of appropriate subjects in patient-oriented research and the identification of innovative results in epidemiological studies. At the same time, the integration of medical data faces significant ethical and legal challenges that impose access constraints. Some of these issues can be addressed by making available aggregated instead of raw record-level da...
12 Citations Source Cite
Published on Jan 1, 2014 in Medical Informatics Europe
Catalina Martínez-Costa9
Estimated H-index: 9
(Medical University of Graz),
Dipak Kalra18
Estimated H-index: 18
(University College London),
Stefan Schulz33
Estimated H-index: 33
(Medical University of Graz)
We propose a semantic-driven architecture to improve EHR semantic interoperability. This architecture is constituted by five layers: structured heterogeneous data (i), as found in (un-)standardised clinical information models, which are consumed by a semantic mapping layer (ii), which links the data items to clinical ontologies via user-friendly content patterns. A semantic mediator (iii) then translates these content patterns into ontology-based annotations, which populate a virtual homogeneous...
10 Citations
Published on Oct 1, 2013
Ratnesh Sahay6
Estimated H-index: 6
(Digital Enterprise Research Institute),
Dimitrios Ntalaperas3
Estimated H-index: 3
+ 14 AuthorsKonstantinos A. Tarabanis28
Estimated H-index: 28
A set of well-integrated clinical terminologies is at the core of delivering an efficient clinical trial system. The design and outcomes of a clinical trial can be improved significantly through an unambiguous and consistent set of clinical terminologies used in a participating clinical institute. However, due to lack of generalised legal and technical standards, heterogeneity exists between prominent clinical terminologies as well as within and between clinical systems at several levels, e.g., ...
5 Citations Source Cite
Published on Nov 1, 2012 in Bioinformatics and Bioengineering
Athos Antoniades6
Estimated H-index: 6
(University of Cyprus),
John A. Keane22
Estimated H-index: 22
(University of Manchester)
+ 9 AuthorsMaria A. Loizidou9
Estimated H-index: 9
The key test for confidence in any association discovered within the medical domain is replication testing. That is, the ability of the association to be detected in independent populations. At the same time, in order to increase the likelihood of discovering statistically significant associations there is a clear need to increase the statistical power of any given study. A key methodology for increasing statistical power is through the use of as many subjects as possible that match a study's in...
7 Citations Source Cite
Published on Jul 16, 2011 in International Joint Conference on Artificial Intelligence
Axel-Cyrille Ngonga Ngomo27
Estimated H-index: 27
(Leipzig University),
Sören Auer16
Estimated H-index: 16
(Leipzig University)
The Linked Data paradigm has evolved into a powerful enabler for the transition from the document-oriented Web into the Semantic Web. While the amount of data published as Linked Data grows steadily and has surpassed 25 billion triples, less than 5% of these triples are links between knowledge bases. Link discovery frameworks provide the functionality necessary to discover missing links between knowledge bases. Yet, this task requires a significant amount of time, especially when it is carried o...
196 Citations Source Cite
Published on Jan 1, 2011
Dipak Kalra18
Estimated H-index: 18
,
Andreas Schmidt4
Estimated H-index: 4
+ 3 AuthorsG. De Moor9
Estimated H-index: 9
Andreas Schmidt has been an eHealth systems leader since 2009. He is involved in projects evaluating opportunities around electronic health record patient level data for F Hoffmann La Roche Pharma Product Development. He has held various roles in clinical development including cardiac safety, business development, and information management at Novartis Pharma AG and Ciba-Geigy AG in the past 20 years. With more than 10 years of working in public healthcare, Andreas has extensive experience in me...
10 Citations
Published on Dec 1, 2009in BMC Psychiatry 2.42
Martin Preisig47
Estimated H-index: 47
,
Gérard Waeber69
Estimated H-index: 69
+ 9 AuthorsVincent Mooser74
Estimated H-index: 74
(GlaxoSmithKline)
Background The Psychiatric arm of the population-based CoLaus study (PsyCoLaus) is designed to: 1) establish the prevalence of threshold and subthreshold psychiatric syndromes in the 35 to 66 year-old population of the city of Lausanne (Switzerland); 2) test the validity of postulated definitions for subthreshold mood and anxiety syndromes; 3) determine the associations between psychiatric disorders, personality traits and cardiovascular diseases (CVD), 4) identify genetic variants that can modi...
121 Citations Source Cite
Published on Dec 1, 2008in BMC Cardiovascular Disorders 1.81
Mathieu Firmann5
Estimated H-index: 5
,
Vladimir Mayor1
Estimated H-index: 1
+ 13 AuthorsXin Yuan3
Estimated H-index: 3
(GlaxoSmithKline)
Background Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess the prevalence of cardiovascular risk factors (CVRFs) in the Caucasian population of Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim of the CoLaus study will be to determine new genetic determinants associated with CVRFs.
383 Citations Source Cite
Published on Mar 16, 2008 in ACM Symposium on Applied Computing
Ratnesh Sahay6
Estimated H-index: 6
(National University of Ireland, Galway),
Waseem Akhtar2
Estimated H-index: 2
(National University of Ireland, Galway),
Ronan Fox7
Estimated H-index: 7
(National University of Ireland, Galway)
The integration of Electronic Patient Record (EPR) systems is at the centre of many of the new regional and national initiatives to integrate clinical processes across department, region, and national levels. Web Service technologies offer significant solutions to provide an interoperable communication infrastructure but are unable to support precise definitions for healthcare messages, functionality, and standards, required for making meaningful integration. The lack of interoperability within ...
19 Citations Source Cite
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