Insights into the pharmacology of new heterocycles embedded with oxopyrrolidine rings: DNA binding, molecular docking, and anticancer studies

In quest to develop effective anticancer drugs, a series of twelve heterocycles (1 − 12) embedded with oxopyrrolidine rings was synthesized. The compounds (1–12) were characterized by microanalysis, FT-IR, UV–Vis and 1H NMR spectroscopy, and mass spectrometry. Experimental DNA binding and computational docking studies were carried out to identify the biological targets of 1–12. The values of DNA binding constants of 1–12 ranged from 1.5 × 104 to...