Are children's vitamin D levels and BMI associated with antibody titers produced in response to 2014–2015 influenza vaccine?

Published on Jul 3, 2017in Human Vaccines & Immunotherapeutics2.592
· DOI :10.1080/21645515.2017.1299837
Chyongchiou J. Lin14
Estimated H-index: 14
(University of Pittsburgh),
Judith M. Martin19
Estimated H-index: 19
(University of Pittsburgh)
+ 7 AuthorsMary Patricia Nowalk36
Estimated H-index: 36
(University of Pittsburgh)
ABSTRACTBackground: Vitamin D is an immunomodulating hormone, which has been associated with susceptibility to infectious diseases.Methods: Serum vitamin D levels in 135 children ages 3–17 y were measured at baseline and hemagglutinin influenza antibody titers were measured pre- and 21 d post influenza vaccination with live attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV). Height and weight were derived from the electronic medical record and were used to calculate body mass index (BMI).Results: Thirty-nine percent of children were ages 3–8 years; 75% were black, 34% were obese (BMI ≥ 95th percentile); vitamin D levels were >20 ng/ml in 55%. In linear regression analyses, post vaccination antibody titers for LAIV B lineages (B Brisbane and B Massachusetts) were significantly higher among those with lower vitamin D levels and among younger participants (P < 0.05). No associations between vitamin D levels and responses to LAIV A strains (A/H1N1 and A/H3N2) or to any IIV strains or l...
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