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Are children's vitamin D levels and BMI associated with antibody titers produced in response to 2014–2015 influenza vaccine?

Published on Jul 3, 2017in Human Vaccines & Immunotherapeutics2.592
· DOI :10.1080/21645515.2017.1299837
Chyongchiou J. Lin14
Estimated H-index: 14
(University of Pittsburgh),
Judith M. Martin19
Estimated H-index: 19
(University of Pittsburgh)
+ 7 AuthorsMary Patricia Nowalk36
Estimated H-index: 36
(University of Pittsburgh)
Sources
Abstract
ABSTRACTBackground: Vitamin D is an immunomodulating hormone, which has been associated with susceptibility to infectious diseases.Methods: Serum vitamin D levels in 135 children ages 3–17 y were measured at baseline and hemagglutinin influenza antibody titers were measured pre- and 21 d post influenza vaccination with live attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV). Height and weight were derived from the electronic medical record and were used to calculate body mass index (BMI).Results: Thirty-nine percent of children were ages 3–8 years; 75% were black, 34% were obese (BMI ≥ 95th percentile); vitamin D levels were >20 ng/ml in 55%. In linear regression analyses, post vaccination antibody titers for LAIV B lineages (B Brisbane and B Massachusetts) were significantly higher among those with lower vitamin D levels and among younger participants (P < 0.05). No associations between vitamin D levels and responses to LAIV A strains (A/H1N1 and A/H3N2) or to any IIV strains or l...
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References30
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In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18–25 years were measured at baseline, and HPV antibody titers were measured one month following the third quadrivalent HPV vaccine dose. Vitamin D levels were ≥30 ng/ml (normal) in 60 males and <30 ng/ml (low) in 113 males. Reverse cumulative distribution curves and scatter plots showed higher antibody titers with low vitamin D for all vaccine strains (P < 0.05). I...
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Objective: Whether vitamin D deficiency and insufficiency are associated with childhood asthma remains unclear. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin D deficiency and insufficiency and the risk of childhood asthma. Methods: Pertinent studies were identified by searching of PubMed and Web of Knowledge. The random effect model was used to combine the results. Meta-regression and subgroups analyses were used to explore potential sources...
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#1Marcos Pereira-Santos (UFBA: Federal University of Bahia)H-Index: 4
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Summary Over the past decade, there have been an increasing number of studies on the association between vitamin D deficiency and anthropometric state. However, we did not identify any meta-analyses of the relationship between obesity and vitamin D deficiency in different age groups. Thus, we evaluated the association between obesity and vitamin D deficiency. We searched for observational studies published up to April 2014 in PubMed/Medline, Web of Science and Scopus databases. We performed a me...
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#3Margaret L. Russell (U of C: University of Calgary)H-Index: 23
Last. Mark Loeb (McMaster University)H-Index: 55
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Background Vaccination is an important strategy in the prevention of influenza, but immunologic response to vaccination can vary widely. Recent studies have shown an association between serum 25-hydroxyvitamin D (25[OH]D) levels and immune function. The purpose of this study was to determine if serum 25(OH)D level correlates with influenza vaccine immunogenicity in children and adolescents. Methods We conducted a prospective cohort study of children age 3 to 15 years of age vaccinated with triva...
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#3Margaret L. Russell (U of C: University of Calgary)H-Index: 23
Last. Mark Loeb (McMaster University)H-Index: 55
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Background: Obesity is an independent risk factor for morbidity and mortality from pandemic influenza H1N1. Influenza is a significant public health threat, killing an estimated 250 000–500 000 people worldwide each year. More than one in ten of the world's adult population is obese and more than two-thirds of the US adult population is overweight or obese. No studies have compared humoral or cellular immune responses to influenza vaccination in healthy weight, overweight and obese populations d...
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