The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice
Abstract
Glucagon-like peptide 1 (GLP-1) is necessary for normal gluco-regulation, and it has been widely presumed that this function reflects the actions of GLP-1 released from enteroendocrine L cells. To test the relative importance of intestinal versus pancreatic sources of GLP-1 for physiological regulation of glucose, we administered a GLP-1R antagonist, exendin-[9-39] (Ex9), to mice with tissue-specific reactivation of the preproglucagon gene...
Paper Details
Title
The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice
Published Date
Apr 1, 2017
Journal
Volume
25
Issue
4
Pages
927 - 934.e3
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