Abstract 11344: Impaired SIRT1 Nucleocytoplasmic Shuttling in the Senescent Heart during Ischemic Stress
Abstract
Background - A decreased ability to tolerate ischemic stress with aging is observed in both animal models and humans. A ‘longevity’ gene, sirtuin 1 (SIRT1), has been reported to attenuate the age-dependent induction of left ventricular dysfunction. We hypothesize that SIRT1 is involved in intolerance of the aged heart to ischemic stress.
Methods and Results - Male C57BL/6 young (4-6 months) and aged (24-26 months) mice were used to determine...
Paper Details
Title
Abstract 11344: Impaired SIRT1 Nucleocytoplasmic Shuttling in the Senescent Heart during Ischemic Stress
Published Date
Nov 20, 2012
Journal
Volume
126
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