Trisomy of the Down Syndrome Critical Region Suppresses Precursor B-Cell Differentiation and Promotes B-Cell Transformation Associated with Altered Expression of Polycomb Repressor Complex 2 Targets

Blood20.30
Volume: 120, Issue: 21, Pages: 115 - 115
Published: Nov 16, 2012
Abstract
115 null null Extra copies of chromosome 21 (polysomy 21) is the most common somatic aneuploidy in B-cell acute lymphoblastic leukemia (B-ALL), including >90% of cases with high hyperdiploidy. In addition, children with Down syndrome (DS) have a 20-fold increased risk of developing B-ALL, of which ∼60% harbor null CRLF2 null rearrangements. To examine these associations within genetically defined models, we investigated B-lineage phenotypes in...
Paper Details
Title
Trisomy of the Down Syndrome Critical Region Suppresses Precursor B-Cell Differentiation and Promotes B-Cell Transformation Associated with Altered Expression of Polycomb Repressor Complex 2 Targets
Published Date
Nov 16, 2012
Journal
Volume
120
Issue
21
Pages
115 - 115
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