Match!

Gender-related psychopathology in opioid use disorder: Results from a representative sample of Italian addiction services

Published on Aug 1, 2017in Addictive Behaviors2.96
· DOI :10.1016/j.addbeh.2017.03.010
Beniamino Leone3
Estimated H-index: 3
(CUA: The Catholic University of America),
Marco Di Nicola21
Estimated H-index: 21
(CUA: The Catholic University of America)
+ 8 AuthorsFabio Lugoboni17
Estimated H-index: 17
Cite
Abstract
Abstract Aims Gender and psychiatric comorbidity seem to influence patients' inter-individual response to Opioid Substitution Treatments (OST) in Opioid Use Disorder (OUD) management. The aim of the study was to assess psychopathological dimensions in an Italian sample of OUD individuals entering a methadone/buprenorphine maintenance program; secondary, we evaluated the possible gender-specific differences within the psychopathological profiles. Methods In a cross-sectional study, we recruited 1052 (792 male; 260 female) OUD subjects receiving OST. All patients underwent a clinical and psychometric evaluation assessing demographics, psychiatric history, psychopathological features via the Symptom Checklist-90-Revised (SCL-90-R), and were prescribed psychopharmacological treatments. Results Our results reveal gender-specific differences in a real-world sample of opioid-maintained OUD individuals attending public addiction services in Italy. Compared to men, women reported higher scores in both General Symptomatic Index (GSI) and in all the SCL-90-R sub-scales. No impact of pharmacological treatment was detected. Finally, regression analysis revealed that being in methadone-maintenance group was significantly associated with high GSI scores in the male, but not female, group. Conclusions Increasing the knowledge of psychopathological dimensions in patients with OST, with relevance to gender differences, is important for a better understanding of factors that influence the outcome and for further development in gender-tailored strategies.
  • References (27)
  • Citations (0)
Cite
References27
Newest
Published on May 9, 2016in Cochrane Database of Systematic Reviews7.75
Suzanne Nielsen20
Estimated H-index: 20
(NDARC: National Drug and Alcohol Research Centre),
Briony Larance19
Estimated H-index: 19
(NDARC: National Drug and Alcohol Research Centre)
+ 3 AuthorsNicholas Lintzeris30
Estimated H-index: 30
Background There are increasing concerns regarding pharmaceutical opioid harms including overdose and dependence, with an associated increase in treatment demand. People dependent on pharmaceutical opioids appear to differ in important ways from people who use heroin, yet most opioid agonist treatment research has been conducted in people who use heroin. Objectives To assess the effects of maintenance agonist pharmacotherapy for the treatment of pharmaceutical opioid dependence. Search methods T...
Published on May 1, 2016in American Journal of Psychiatry13.65
Yoram Yovell6
Estimated H-index: 6
,
Gali Bar1
Estimated H-index: 1
+ 6 AuthorsJaak Panksepp86
Estimated H-index: 86
Objective:Suicidal ideation and behavior currently have no quick-acting pharmacological treatments that are suitable for independent outpatient use. Suicidality is linked to mental pain, which is modulated by the separation distress system through endogenous opioids. The authors tested the efficacy and safety of very low dosages of sublingual buprenorphine as a time-limited treatment for severe suicidal ideation.Method:This was a multisite randomized double-blind placebo-controlled trial of ultr...
Published on Jan 1, 2016in Addiction6.85
Jane Mounteney7
Estimated H-index: 7
(European Monitoring Centre for Drugs and Drug Addiction),
Paul Griffiths50
Estimated H-index: 50
(European Monitoring Centre for Drugs and Drug Addiction)
+ 3 AuthorsRoland Simon6
Estimated H-index: 6
(European Monitoring Centre for Drugs and Drug Addiction)
Aim A central task for the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is to produce an annual report of the latest data available on drug demand and drug supply in Europe. This paper is intended to facilitate a better understanding of, and easier access to, the main quantitative European level data sets available in 2015. Methods The European reporting system formally covers all 28 European Union (EU) Member States, Norway and Turkey and incorporates multiple indicators alo...
Published on Jan 1, 2016in American Journal on Addictions1.95
Joni Teoh Bing Fei2
Estimated H-index: 2
(University Malaya Medical Centre),
Anne Yee8
Estimated H-index: 8
(University Malaya Medical Centre),
Mohamad Hussain Bin Habil1
Estimated H-index: 1
(University Malaya Medical Centre)
Co-occurring psychiatric disorders are among the difficulties faced by patients with opioid dependence on methadone maintenance therapy (MMT). This study aims to assess the prevalence of psychiatric comorbidity among patients on MMT, the factors predicting psychiatric comorbidity and to examine the association between psychiatric comorbidity and quality of life.A total of 225 male patients on MMT in a tertiary hospital in Malaysia were assessed for psychiatric comorbidity and substance use disor...
Published on Dec 21, 2015in American Journal on Addictions1.95
Joni Teoh Bing Fei Mb, BCh, Bao1
Estimated H-index: 1
(University Malaya Medical Centre),
Anne Yee Mb, BCh, Bao, Mpm and1
Estimated H-index: 1
(University Malaya Medical Centre),
Mpm Mohamad Hussain Bin Habil Mbbs1
Estimated H-index: 1
(University Malaya Medical Centre)
Background and Objectives Co-occurring psychiatric disorders are among the difficulties faced by patients with opioid dependence on methadone maintenance therapy (MMT). This study aims to assess the prevalence of psychiatric comorbidity among patients on MMT, the factors predicting psychiatric comorbidity and to examine the association between psychiatric comorbidity and quality of life. Methods A total of 225 male patients on MMT in a tertiary hospital in Malaysia were assessed for psychiatric ...
Published on Dec 1, 2015in Biology of Sex Differences3.19
Monica Bawor12
Estimated H-index: 12
(St. Joseph's Healthcare Hamilton),
Brittany B. Dennis13
Estimated H-index: 13
(St. Joseph's Healthcare Hamilton)
+ 10 AuthorsGuillaume Paré48
Estimated H-index: 48
(McMaster University)
Background Despite the growing numbers of men and women with opioid use disorder in Canada, sex-specific issues in treatment have not been re-examined in the current population of patients with opioid addiction. We aimed to evaluate sex differences in substance use, health, and social functioning among men and women currently receiving methadone treatment for opioid use disorder in Ontario, Canada.
Published on Dec 3, 2014in Frontiers in Psychiatry3.16
Mauro Pettorruso12
Estimated H-index: 12
(CUA: The Catholic University of America),
Luisa De Risio11
Estimated H-index: 11
(CUA: The Catholic University of America)
+ 3 AuthorsLuigi Janiri37
Estimated H-index: 37
(CUA: The Catholic University of America)
Bipolar disorders (BDs) and addictions constitute reciprocal risk factors and are best considered under a unitary perspective. The concepts of allostasis and allostatic load (AL) may contribute to the understanding of the complex relationships between BD and addictive behaviors. Allostasis entails the safeguarding of reward function stability by recruitment of changes in the reward and stress system neurocircuitry and it may help to elucidate neurobiological underpinnings of vulnerability to add...
Published on Jul 1, 2014in JAMA Psychiatry15.92
Theodore J. Cicero54
Estimated H-index: 54
(WashU: Washington University in St. Louis),
Matthew S. Ellis11
Estimated H-index: 11
(WashU: Washington University in St. Louis)
+ 1 AuthorsP KurtzSteven28
Estimated H-index: 28
(NSU: Nova Southeastern University)
Importance Over the past several years, there have been a number of mainstream media reports that the abuse of heroin has migrated from low-income urban areas with large minority populations to more affluent suburban and rural areas with primarily white populations. Objective To examine the veracity of these anecdotal reports and define the relationship between the abuse of prescription opioids and the abuse of heroin. Design, Setting, and Participants Using a mixed-methods approach, we analyzed...
Published on Apr 9, 2014in JAMA51.27
Yngvild Olsen1
Estimated H-index: 1
,
Joshua M. Sharfstein13
Estimated H-index: 13
The death of Philip Seymour Hoffman from a heroin overdose tragically adds another name to the list of celebrities who have lost their lives to addiction. Increasing numbers of overdoses from prescription opioids and a more recent increase in heroin-associated fatalities have caused heartbreak in communities across the country. More than 30 000 deaths from unintentional drug overdose were reported in the United States in 2010, the most recent year for which data are available.1