DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells
Abstract
Pigs are proposed to be suitable large animal models for test of the efficacy and safety of induced pluripotent stem cells (iPSCs) for stem cell therapy, but authentic pig ES/iPS cell lines with germline competence are rarely produced. The pathways or signaling underlying the defective competent pig iPSCs remain poorly understood. By improving induction conditions using various small chemicals, we generated pig iPSCs that exhibited high...
Paper Details
Title
DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells
Published Date
Mar 2, 2017
Journal
Volume
12
Issue
3
Pages
e0173047 - e0173047
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