Listeria monocytogenesinduces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice

Volume: 47, Issue: 5, Pages: 830 - 840
Published: Apr 13, 2017
Abstract
Type I interferons (IFNs) induce a detrimental response during Listeria monocytogenes (L. monocytogenes) infection. We were interested in identifying mechanisms linking IFN signaling to negative host responses against L. monocytogenes infection. Herein, we found that infection of myeloid cells with L. monocytogenes led to a coordinated induction of type I IFNs and activation of the integrated stress response (ISR). Infected cells did not induce...
Paper Details
Title
Listeria monocytogenesinduces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice
Published Date
Apr 13, 2017
Volume
47
Issue
5
Pages
830 - 840
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