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Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles

Published on Mar 1, 2017in International Journal of Nanomedicine4.471
路 DOI :10.2147/IJN.S132043
Kyoung Mee Kim3
Estimated H-index: 3
,
Hyun Kyung Lim4
Estimated H-index: 4
+ 1 AuthorsJoohee Jung9
Estimated H-index: 9
Abstract
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  • Citations (9)
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We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavon...
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#1Debjani Baidya (Poona College of Arts Science & Commerce)H-Index: 1
#2Jeetendra Prasad Kushwaha (Poona College of Arts Science & Commerce)H-Index: 1
Last. Sharvil Patil (Poona College of Arts Science & Commerce)H-Index: 5
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AbstractChrysin (CH), a phytoconstituent has numerous pharmacological activities including anticancer activity. However, CH suffers from a drawback of poor aqueous solubility and in turn poor bioav...
1 CitationsSource
#1Yan Liu (CAS: Chinese Academy of Sciences)H-Index: 10
#2Shu-Xi Jing (CAS: Chinese Academy of Sciences)H-Index: 9
Last. Sheng-Hong Li (CAS: Chinese Academy of Sciences)H-Index: 22
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Covering: 1960s to end of August 2018 Plant glandular trichomes (GTs) are adaptive structures that are well known as 鈥減hytochemical factories鈥 due to their impressive capacity to biosynthesize and store large quantities of specialized natural products. The natural products in GTs are chemically diverse and mostly function as defense chemicals, therefore GTs are frequently regarded as 鈥渢he first defense line鈥 of plants against biotic and abiotic stresses. More importantly, many GT natural product...
1 CitationsSource
#1Kripi Vohra (Maharshi Dayanand University)H-Index: 1
#2Harish Dureja (Maharshi Dayanand University)H-Index: 13
Last. Rohit Dutt (GD Goenka University)H-Index: 3
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1 CitationsSource
#1Joana Marques (University of Aveiro)H-Index: 12
#2Maria S. Santos (University of Aveiro)H-Index: 61
Last. Susana S. Braga (University of Aveiro)H-Index: 17
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Abstract This study describes a simple, two-step method for obtaining ruthenium(II) trithiacyclononane ([9]aneS 3 ) flavonate complexes in yields of 23 to 43%. With 7,3鈥,4鈥-trihydroxyflavone (thflv), a neutral complex, [Ru(II)([9]aneS 3 )(DMSO)(thflv)] ( 1 ), is formed by coordination at the catechol group. With chrysin (chrys) and tectochrysin (tchrys), Ru(II) binds to the chromenone fragment to form cationic complexes that are isolated as [Ru(II)([9]aneS 3 )(chrys)(DMSO)]Cl ( 2 ) and [Ru(II)([...
1 CitationsSource
#1Ghassan M. Sulaiman (University of Technology, Iraq)H-Index: 9
#2Majid S. Jabir (University of Technology, Iraq)H-Index: 6
Last. Anaheed H. Hameed (University of Technology, Iraq)H-Index: 2
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Chrysin, as a flavone, is a promising drug candidate because of its multifaceted properties, such as anti-inflammatory, antioxidant and anticancer. However, its poor bioavailability is a bottleneck for pharmaceutical applications. To enhance the bioactive effects, chrysin-loaded poly (D,L-lactic-co-glycolic acid) and polyvinyl alcohol were successfully prepared to overcome problems associated with chrysin. The properties of modified nanochrysin were analysed by in vitro dissolution study, XRD, F...
6 CitationsSource
#1Eun-Sook Kim (Duksung Women's University)H-Index: 10
#2S. Y. Kim (Duksung Women's University)H-Index: 1
Last. Aree Moon (Duksung Women's University)H-Index: 28
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C-reactive protein binds to integrin 伪2 and Fc纬 receptor I, leading to breast cell adhesion and breast cancer progression
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