Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles

Published on Mar 1, 2017in International Journal of Nanomedicine4.471
路 DOI :10.2147/IJN.S132043
Kyoung Mee Kim3
Estimated H-index: 3
Hyun Kyung Lim4
Estimated H-index: 4
+ 1 AuthorsJoohee Jung9
Estimated H-index: 9
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We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavon...
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Abstract This study describes a simple, two-step method for obtaining ruthenium(II) trithiacyclononane ([9]aneS 3 ) flavonate complexes in yields of 23 to 43%. With 7,3鈥,4鈥-trihydroxyflavone (thflv), a neutral complex, [Ru(II)([9]aneS 3 )(DMSO)(thflv)] ( 1 ), is formed by coordination at the catechol group. With chrysin (chrys) and tectochrysin (tchrys), Ru(II) binds to the chromenone fragment to form cationic complexes that are isolated as [Ru(II)([9]aneS 3 )(chrys)(DMSO)]Cl ( 2 ) and [Ru(II)([...
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Chrysin, as a flavone, is a promising drug candidate because of its multifaceted properties, such as anti-inflammatory, antioxidant and anticancer. However, its poor bioavailability is a bottleneck for pharmaceutical applications. To enhance the bioactive effects, chrysin-loaded poly (D,L-lactic-co-glycolic acid) and polyvinyl alcohol were successfully prepared to overcome problems associated with chrysin. The properties of modified nanochrysin were analysed by in vitro dissolution study, XRD, F...
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